2 Minute Medicine
Concise. Curated. Evidence.™
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Latest posts
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FDA identifies safety concerns for compounded peptide injections, including reports of death
The FDA lists potential safety risks for compounded peptide injections, including reported deaths associated with GHRP-2 and ipamorelin acetate. The post FDA identifies safety concerns for compounded peptide injections, including reports of death first appeared on 2 Minute…
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In topline phase 3 results, nomelcitinib improved PASI 90 and PGA 0/1 responses versus placebo in plaque psoriasis
Topline phase 3 results showed nomelcitinib improved psoriasis response measures versus placebo, with no new safety signals reported. The post In topline phase 3 results, nomelcitinib improved PASI 90 and PGA 0/1 responses versus placebo in plaque psoriasis first appeared on 2…
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Intraosseous cefuroxime (Ceftin) may improve tissue delivery compared to intravenous administration during total knee arthroplasty
1. In adult patients undergoing robotic-assisted total knee arthroplasty (RA-TKA) for knee osteoarthritis, intraosseous cefuroxime (Ceftin) was significantly associated with higher concentrations of local tissue cefuroxime compared to intravenous administration. The post…
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2 Minute Medicine Rewind November 2, 2026
1. Zavegepant, a calcitonin gene-related peptide receptor antagonist (CGRPRA), is well-tolerated and significantly improves resolution of migraine symptoms in Asian adults with migraines. The post 2 Minute Medicine Rewind November 2, 2026 first appeared on 2 Minute Medicine .…
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Early mitral valve surgery may improve long-term survival in asymptomatic severe mitral regurgitation
1. Among patients with asymptomatic severe primary mitral regurgitation, early mitral valve surgery improved long-term survival compared with watchful waiting. The post Early mitral valve surgery may improve long-term survival in asymptomatic severe mitral regurgitation first…
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CDC reports increasing early-season influenza activity and at least 900 deaths nationwide
The CDC estimates at least 1,000,000 illnesses, 16,000 hospitalizations, and 900 deaths from influenza as early-season activity increases nationwide. The post CDC reports increasing early-season influenza activity and at least 900 deaths nationwide first appeared on 2 Minute…
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A concentrated exposure therapy intervention may be more effective than digital cognitive behavioural therapy in obsessive-compulsive disorder
1. Concentrated exposure therapy was associated with greater and more sustained reductions in obsessive-compulsive disorder symptom severity compared to an established internet-based cognitive behavioral therapy. The post A concentrated exposure therapy intervention may be more…
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Routine CT scans show steeper fat loss years before pancreatic cancer diagnosis
1. An artifical intelligence (AI) model flagged pancreatic cancer in CT scans years before diagnosis, with 2-3x the sensitivity of expert radiologists. 2. This model allows CTs obtained for unrelated indications to be used for screening, especially in high risk groups. The post…
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Post-hoc CHARM analysis linked CIRARA with better functional outcomes in selected patients with severe stroke
A post-hoc CHARM analysis associated CIRARA with better 90-day outcomes in selected severe stroke patients identified using automated NCCT analysis. The post Post-hoc CHARM analysis linked CIRARA with better functional outcomes in selected patients with severe stroke first…
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Zemprocitinib sustained clinical responses through Week 76 in rheumatoid arthritis after inadequate response to biologic therapy
Long-term topline results showed sustained clinical responses with zemprocitinib through Week 76 in rheumatoid arthritis after inadequate response to biologic therapy. The post Zemprocitinib sustained clinical responses through Week 76 in rheumatoid arthritis after inadequate…
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In late-breaking phase 3 results, pozdeutinurad lowered serum urate through 12 months in patients with uncontrolled gout
Pozdeutinurad lowered serum urate below 6 mg/dL at month 6 in more patients with uncontrolled gout than placebo, with reductions sustained through month 12. The post In late-breaking phase 3 results, pozdeutinurad lowered serum urate through 12 months in patients with…
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Care recommendations by large language models were associated with higher healthcare costs
1. Across 200 cases, large language models (LLMs) recommended diagnostic tests and referrals that were associated with 3.2 times the cost compared to physician plans. 2. Prompts that accounted for healthcare costs coincided with lower diagnostic agreement. The post Care…
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FDA approves dostarlimab (Jemperli) for certain patients with locally advanced rectal cancer
1. Interim results from the phase 2 AZUR-1 trial have demonstrated that at a median follow-up of 2 years. nearly 75% of patients did not require surgery, radiotherapy, or chemotherapy after a 6-month regimen of Jemperli. 2. Up to 3% of stage II or stage III locally advanced…
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In topline phase 3 results, retatrutide lowered A1C more and reduced weight more than semaglutide 2 mg at 80 weeks
In topline phase 3 results, retatrutide lowered A1C and body weight more than semaglutide 2 mg in adults with type 2 diabetes at 80 weeks. The post In topline phase 3 results, retatrutide lowered A1C more and reduced weight more than semaglutide 2 mg at 80 weeks first appeared…