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Latest posts
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Common T-Cell Receptors Found in Multiple Cancers
A massive dataset has revealed how different patients share the same T-cell receptors against different cancers, revealing the value of computer analysis of information gleaned from routine clinical genomics testing. The post Common T-Cell Receptors Found in Multiple Cancers…
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Haplotype-Based ASOs Can Bypass Bespoke Rare Disease Drug Design
Targeting shared haplotypes could expand personalized ASO therapies for SCN2A disorders, with four drugs potentially covering 76% of genetic profiles. The post Haplotype-Based ASOs Can Bypass Bespoke Rare Disease Drug Design appeared first on Inside Precision Medicine .
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Ultrasound Implant Could Allow Real-Time Monitoring of Spinal Cord Injury
A miniature ultrasound device can be temporarily implanted at the site of a spinal cord injury to monitor patients in real time and support recovery. The post Ultrasound Implant Could Allow Real-Time Monitoring of Spinal Cord Injury appeared first on Inside Precision Medicine .
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AI Marginally Improves Mortality Prediction from Cardiac MRI
AI measured left-ventricular ejection fraction faster and slightly more accurately than clinicians, supporting its potential as a first-line cardiac imaging tool with expert oversight. The post AI Marginally Improves Mortality Prediction from Cardiac MRI appeared first on Inside…
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SuperAgers Offer Window on Alzheimer’s Risk
A machine-learning framework can judge where a person's brain function lies between SuperAgers and a diagnosis of Alzheimer’s disease. The post SuperAgers Offer Window on Alzheimer’s Risk appeared first on Inside Precision Medicine .
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New PET Scan Technology Identifies Hidden Myeloma Cells Missed on Conventional Scans
The findings suggest that targeting CD38 on cancer cells could help physicians uncover hidden disease and guide treatment decisions. The post New PET Scan Technology Identifies Hidden Myeloma Cells Missed on Conventional Scans appeared first on Inside Precision Medicine .
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New Standard-of-Care for KRAS G12C-Mutated Advanced NSCLC
The next-generation KRAS G12C inhibitor divarasib improved progression-free and overall survival compared with sotorasib or adagrasib in previously treated advanced NSCLC. The post New Standard-of-Care for KRAS G12C-Mutated Advanced NSCLC appeared first on Inside Precision…
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Surveillance Mammography Doesn’t Improve Survival in Older Women with Breast Cancer History
This study, which involved data from almost 10,000 women, suggests healthcare resources could be better used and that new approaches to following these women are needed to improve detection of new tumors. The post Surveillance Mammography Doesn’t Improve Survival in Older Women…
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Insilico’s AI-Designed Mesothelioma Treatment Shows Early Promise
Insilico reports good early safety and efficacy results for its AI-designed mesothelioma treatment, ISM6331, with 68.2% of participants showing tumor shrinkage or stable disease at their first assessment. The post Insilico’s AI-Designed Mesothelioma Treatment Shows Early Promise…
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Ryan Beal: Getting Under Cancer’s Skin
In this Behind the Breakthroughs , Dyve Biosciences' transdermal delivery approach targets acidic microenvironments that promote cancer cell growth and inflammation to treat immunologic and oncologic diseases. The post Ryan Beal: Getting Under Cancer’s Skin appeared first on…
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Peanut Allergy No Longer Found in 35% of Previously Diagnosed Children
An Australian study suggests a supervised food challenge may be the best way to diagnose peanut allergy in young children, as clinical history and allergy testing alone were not enough to accurately diagnose many infants. The post Peanut Allergy No Longer Found in 35% of…
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Experimental Lupus Therapy Targets Harmful Immune Cells While Sparing Healthy Ones
A new experimental approach to treating lupus targets an abnormality in how immune cells respond to the hormone prolactin. The strategy reduced harmful immune activity and prevented kidney damage in mice while largely preserving healthy immune cells, raising hopes for more…
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Base-Editing Gene Therapy Successfully Targets Inherited Disorder
In vivo gene editing has successfully treated a patient with alpha-1 antitrypsin deficiency, a condition affecting the liver and lungs. The post Base-Editing Gene Therapy Successfully Targets Inherited Disorder appeared first on Inside Precision Medicine .
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Cervical Cancer Cases and Deaths Increasing, Particularly in Africa
Cervical cancer rates and deaths are increasing around the world, with the highest rates in developing countries and regions like sub-Saharan Africa. The post Cervical Cancer Cases and Deaths Increasing, Particularly in Africa appeared first on Inside Precision Medicine .
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Cancer’s Genetic Weak Spot Offers New Route to Target WNT Signaling
The Weill Cornell Medicine findings point to a new strategy for blocking the WNT signaling pathway, which is overactive in nearly all colorectal cancers and many breast, lung, liver, and prostate tumors. The post Cancer’s Genetic Weak Spot Offers New Route to Target WNT…
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Molecular Profiling May Help Predict Immunotherapy Outcomes in Small Cell Lung Cancer
A new study suggests that gene expression patterns and tumor immune characteristics could help identify patients with small cell lung cancer who are more likely to experience favorable outcomes following immunotherapy. The post Molecular Profiling May Help Predict Immunotherapy…
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Wearables and AI Predict Hypertensive Crisis Up to Three Days in Advance
The AI tool used in the study analyzed 47 features, including blood pressure fluctuations, changes during sleep, morning blood pressure increases, heart rate, and heart rate variability, to predict a hypertensive crisis within the next 72 hours. The post Wearables and AI Predict…
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Modern Hormone Therapy Shows No Increased Heart Risk in Long-Term Study
New long-term evidence suggests contemporary hormone replacement therapy does not increase the risk of heart disease, stroke, blood clots, or premature death in women who begin treatment before age 60. The post Modern Hormone Therapy Shows No Increased Heart Risk in Long-Term…
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Five-Year PHERGain Results Support Chemotherapy-Free Treatment for Some Breast Cancer Patients
Five-year follow-up from the PHERGain trial suggests that selected patients with HER2-positive early breast cancer may avoid chemotherapy without compromising long-term disease control. The post Five-Year PHERGain Results Support Chemotherapy-Free Treatment for Some Breast…
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Encoded Therapeutics Reports Promising Results for Dravet Gene Therapy
Encoded Therapeutics reports promising early Phase I/II results for its AAV gene therapy developed to treat children with Dravet syndrome, a rare neurodevelopmental disorder characterized by severe epilepsy. The post Encoded Therapeutics Reports Promising Results for Dravet Gene…